• Name: ARA-290 / Cibinetide – Peptide
• Sequence: Gly‑Ala‑Pro‑Gly‑Pro‑Lys‑Lys‑Lys‑Lys‑Lys‑Gly
• Peptide Length: 11 amino acids
• CAS Number: 1392112‑10‑1
• Molecular Formula: C₅₄H₉₉N₁₉O₁₅
• Molecular Weight: ~1250.5 g/mol
• COA (certificate of analysis) provided: ARA290 COA 99.34%
• Purity: 99.34% HPLC

Product Video:

ARA‑290 — also known as Cibinetide — is a small, engineered peptide designed to activate the innate repair receptor (IRR), a specific receptor complex involved in reducing inflammation and promoting tissue recovery. It’s derived from a tiny portion of erythropoietin (EPO) but without the blood‑thickening or erythropoiesis effects of EPO itself.

What ARA‑290 Does

Reduces Inflammation

• Selectively activates the EPOR–CD131 (IRR) receptor, which down‑regulates inflammatory signaling.
• Lowers pro‑inflammatory cytokines without suppressing the immune system globally.
• Helps calm chronic inflammatory states, especially in nerve and micro-vascular tissue.

Promotes Nerve Repair

• Improves small‑fiber nerve function, which is why it’s studied for small‑fiber neuropathy, including neuropathy caused by diabetes or sarcoidosis.
• Enhances nerve regeneration and reduces neuropathic pain signals.

Improves Micro-vascular Function

• Restores endothelial health and micro-circulation.
• Helps tissues receive better oxygen and nutrient delivery during recovery.

Protects Against Tissue Damage

• Reduces oxidative stress and cellular injury in multiple tissues.
• Supports recovery after ischemia, inflammation, or metabolic stress.

Does NOT Increase Red Blood Cell Count

• Unlike erythropoietin, ARA‑290 does not stimulate erythropoiesis.
• This makes it safer for long‑term use in research settings.

Key Areas of Research

• Small‑fiber neuropathy (diabetic, sarcoidosis‑related, idiopathic)
• Chronic inflammatory conditions
• Microvascular dysfunction
• Ischemia‑reperfusion injury
• Autoimmune‑related nerve damage

Why It’s Considered Unique

ARA‑290 is one of the few peptides that targets the innate repair receptor, a pathway specifically designed to resolve inflammation and promote healing without the side effects of steroids or immuno suppressants.

Legal and Safety Information;

Quantum Peptides products are provided exclusively for laboratory research and educational use.

They are not approved for human or veterinary applications.

These materials are not intended to diagnose, treat, cure, or prevent any medical condition.

All use must adhere to applicable laws and regulatory requirements.

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