Name: CJC-1295 MOD GRF 1-29 / without DAC
Sequence: Tyr‑Ala‑Asp‑Ala‑Ile‑Phe‑Thr‑Asn‑Ser‑Tyr‑Arg‑Lys‑Val‑Leu‑Ala‑Gln‑Leu‑Ser‑Ala‑Arg‑Lys‑Leu‑Leu‑Gln‑Asp‑Ile‑Leu‑Ser‑Arg‑NH₂
Peptide Length: 29 amino
CAS Number: 863288‑34‑0
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: ≈ 3367.9 g/mol
COA (certificate of analysis) provided: cjc1295_no_dac_coa_99.32%

Purity: 99.32% HPLC

Product Video:

CJC‑1295 (MOD GRF 1‑29) is a synthetic growth hormone–releasing hormone (GHRH) analogue engineered to enhance stability and receptor affinity compared to endogenous GHRH(1‑29). The “without DAC” variant does not include the Drug Affinity Complex modification, resulting in a short‑acting profile suitable for pulsatile GH‑axis studies.

CJC‑1295 (MOD GRF 1‑29) is studied for its role as a growth hormone–releasing hormone (GHRH) analogue. It binds to the GHRH receptor and is used in research to explore:
A. Pulsatile GH Release

Enhances natural GH pulses

Supports physiological GH rhythm

Does not flatten GH secretion like long‑acting analogues

B. Synergy With GHRPs
Often studied in combination with:

GHRP‑2

GHRP‑6

Ipamorelin

Hexarelin

Together they activate dual pathways (GHRH + ghrelin receptor).
C. Increased Stability vs Native GHRH
The 4 amino‑acid substitutions:

Improve resistance to enzymatic breakdown

Extend half‑life

Increase receptor affinity

D. Research Areas

GH/IGF‑1 axis

Pituitary signalling

Endocrine feedback loops

Peptide stability and receptor pharmacology.

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