Name: MGF (Mechano Growth Factor)
Sequence: (24 AA)
Peptide Length: 24‑amino‑acid fragment
CAS Number: 116541‑27‑4
Molecular Formula: C₁₂₁H₂₀₀N₄₂O₃₉
Molecular Weight: ≈ 2867.2 g/mol
COA (certificate of analysis) provided: mgf_coa_99.09%
Purity: 99.09% HPLC

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MGF is a splice variant of IGF‑1, specifically the IGF‑1Ec isoform. It is produced naturally in muscle tissue in response to mechanical overload, damage, or resistance training. In research settings, MGF is studied for its role in muscle repair, satellite cell activation, and tissue regeneration.
The form used in peptide research is the C‑terminal 24‑amino‑acid fragment, not the full IGF‑1Ec protein.
Biological Role (Research Context)
MGF is associated with:

Activation of muscle satellite cells

Local tissue repair signalling

Upregulation of muscle hypertrophy pathways

Response to mechanical stress or micro‑trauma

It is distinct from IGF‑1 LR3 or IGF‑1 DES because it acts locally rather than systemically.

1. Activates Muscle Satellite Cells
MGF is strongly associated with the activation and proliferation of satellite cells, the stem‑cell‑like precursors responsible for:

repairing damaged muscle fibres

generating new myonuclei

supporting hypertrophy and regeneration

This is the core reason MGF is studied in muscle‑repair models.

2. Signals Local Tissue Repair
MGF acts as a local autocrine/paracrine signal, meaning it works at the site of muscle damage rather than circulating systemically.
Research shows it contributes to:

early‑stage tissue repair

upregulation of growth‑related genes

restoration of damaged fibres

3. Shifts Muscle Cells Toward Growth & Recovery
MGF appears to influence:

myoblast proliferation (cell number increase)

reduced differentiation in early stages (keeps cells in a growth‑ready state)

This is the opposite of IGF‑1 LR3, which promotes differentiation. Together, they form a two‑phase repair system in muscle biology.

4. Responds to Mechanical Stress
MGF expression spikes when muscle experiences:

eccentric loading, high‑tension contractions, micro‑damage, This is why it’s called Mechano‑Growth Factor.

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