Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight: 2174.62 g/mol
CAS Number: 1627580‑64‑6
COA (certificate of analysis) provided: mots-c_coa_99.32%
Purity: 99.32% HPLC

Product Video:

🧬 MOTS‑c — Scientific Overview
What It Is
MOTS‑c (Mitochondrial ORF‑encoded Peptide, 16 amino acids) is a mitochondrial‑derived peptide (MDP) encoded within the 12S rRNA region of mitochondrial DNA. Unlike most peptides, which originate from nuclear genes, MOTS‑c is produced from the mitochondrial genome, giving it a unique regulatory profile in cellular metabolism and stress responses.

Amino Acid Length & Sequence

Length: 16 amino acids

Sequence: MRWQEMGYIFYPRKLR

This short peptide is highly conserved across species, highlighting its biological importance.

Primary Biological Functions
1. Metabolic Regulation
MOTS‑c plays a central role in maintaining metabolic homeostasis by:

Enhancing glucose uptake

Improving insulin sensitivity

Activating AMPK, a key energy‑sensing pathway

Supporting mitochondrial function under metabolic stress

2. Stress Response
MOTS‑c translocates to the nucleus during metabolic stress, where it:

Regulates gene expression

Promotes adaptive cellular responses

Helps maintain energy balance

3. Exercise‑Related Effects
Research shows MOTS‑c:

Increases exercise capacity

Enhances fat oxidation

Supports muscle resilience under stress

These findings have made it a major focus in metabolic and longevity research.

Mechanistic Highlights

Activates AMPK → boosts energy production

Modulates folate‑AICAR pathway

Influences nuclear gene expression during stress

Supports mitochondrial integrity

Research Applications
MOTS‑c is widely studied in contexts such as:

Metabolic syndrome

Insulin resistance

Obesity

Age‑related metabolic decline

Exercise physiology

Cellular stress adaptation

Key Distinction
MOTS‑c is part of a unique class of peptides encoded by mitochondrial DNA, alongside Humanin and SHLP peptides. This sets it apart from typical nuclear‑encoded peptides and gives it a distinctive role in metabolic regulation.

Reconstitute with BAC’s Water

When reconstituting peptides, it is crucial to use bacteriostatic water (BAC) to ensure sterility and safety.
BAC water contains 0.9% Benzyl Alcohol and is bacteria-proof, making it the preferred choice for reconstitution.
This method helps preserve the integrity of the peptide and prevents contamination.

To reconstitute a peptide blend, follow these steps:Disinfect both vials and the stoppers with alcohol wipes.
Measure the required amount of BAC water based on the dosage.Mix the peptide powder with the measured BAC water in a sterile syringe.
Inject the solution into the vial and refrigerate at 2–8°C, protected from light.
Use the reconstituted solution within 4 weeks for best potency and safety.

Legal and Safety Information;
Quantum Peptides products are provided exclusively for laboratory research and educational use.
They are not approved for human or veterinary applications.
These materials are not intended to diagnose, treat, cure, or prevent any medical condition.
All use must adhere to applicable laws and regulatory requirements.

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