Type: Synthetic GHRH (1‑29) peptide
Length: 29 amino Acids
Sequence: Tyr–Ala–Asp–Ala–Ile–Phe–Thr–Asn–Ser–Tyr–Arg–Lys–Val–Leu–Gly–Gln–Leu–Ser–Ala–Arg–Lys–Leu–Leu–Gln–Asp–Ile–Met–Ser–Arg–NH₂
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: 3357.91 g/mol

CAS Number: 86168-78-7
Purity: 99.22% HPLC

COA ( Certificate of Analysis) Sermorlelin COA

 

Sermorelin is a synthetic peptide that mimics the natural hypothalamic hormone GHRH, designed to stimulate the pituitary gland to release endogenous growth hormone. Unlike direct GH administration, Sermorelin works by activating the body’s own physiological GH production pathways, leading to a more regulated and pulsatile release.

In clinical and research contexts, it has been studied and used for:

• Growth hormone deficiency (GHD) diagnosis and treatment
• Supporting metabolic function and body composition
• Investigating aging-related decline in GH levels

---

Functional Profile

• Stimulates pituitary GH secretion
• Promotes downstream IGF-1 production
• Supports protein synthesis and tissue repair (research context)

Sermorelin’s role is to stimulate your body’s own growth hormone production, because it is the active 1–29 fragment of natural GHRH. This function is well‑documented in endocrine research and clinical references.

 Core biological action

Sermorelin is a growth hormone–releasing hormone (GHRH) analogue, meaning it binds to GHRH receptors in the pituitary and triggers endogenous GH release. This mechanism preserves the body’s natural feedback loops and pulsatile secretion patterns.

What Sermorelin does

These effects are consistently described in clinical and research literature:

• Stimulates pituitary GH secretion — Sermorelin activates GHRH receptors, increasing growth hormone output.
• Raises IGF‑1 levels — Increased GH leads to higher circulating IGF‑1, which mediates many downstream effects.
• Supports lean body mass — Clinical trials show modest but measurable increases in lean mass.
• Improves skin thickness and elasticity — Repeatedly observed in controlled studies.
• Enhances immune responsiveness — Increased IL‑2 receptor expression and B‑cell activity have been documented.
• Maintains physiological GH rhythms — Unlike exogenous GH, Sermorelin preserves natural pulsatile secretion.

Clinical context

Sermorelin was originally FDA‑approved as Geref for evaluating GH secretion and later for treating pediatric GH deficiency. Although discontinued commercially for economic reasons, it remains widely used in research.

Why its mechanism matters

Because Sermorelin works upstream at the receptor level, it:

• Avoids supraphysiologic GH spikes
• Preserves hypothalamic–pituitary feedback
• Produces more natural GH/IGF‑1 profiles

This makes it fundamentally different from direct GH administration.

 

Legal and Safety Information;
Quantum Peptides products are provided exclusively for laboratory research and educational use.
They are not approved for human or veterinary applications.
These materials are not intended to diagnose, treat, cure, or prevent any medical condition.
All use must adhere to applicable laws and regulatory requirements.

“The photo is for illustration purposes only and includes as much product information as possible. Bottle labels wrap around the container and may vary slightly in design & between batches as part of our anti‑counterfeiting measures.”